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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Epigenetics>DNA Methyltransferase Inhibitors>Lomeguatrib
Lomeguatrib
  • Lomeguatrib

Lomeguatrib NEW

Price $43 $54 $95
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Lomeguatrib CAS No.: 192441-08-0
Purity: 99.62% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameLomeguatrib
DescriptionLomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
In vitroIn the A375M human melanoma xenograft model, intraperitoneal injection of Lomeguatrib (20 mg/kg) treatment was found to inhibit ATase activity.
In vivoIn Raji cells, Lomeguatrib inhibits ATase activity with an IC50 value of 10 nM, while in MCF-7 cells, it effectively inhibits MGMT with an IC50 of 6 nM.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (168.62 mM), Sonication is recommended.
KeywordsLomeguatrib | inhibit | DNMTs | DNA Methyltransferase | PaTrin 2 | DNA MTases | PaTrin2 | Inhibitor
Inhibitors RelatedLevetiracetam | 5-Azacytidine | γ-Oryzanol | Methyl methanesulfonate
Related Compound LibrariesBioactive Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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