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Postion:Product Catalog >API>Hormones and the Endocrine System>Thyroid hormone and antithyroid drugs>Liothyronine sodium
Liothyronine sodium
  • Liothyronine sodium

Liothyronine sodium NEW

Price $8 $6 $2
Package 1kg 100kg 1000kg
Min. Order: 1kg
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-24

Product Details

Product Name: Liothyronine sodium CAS No.: 55-06-1
Min. Order: 1kg Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/24
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
Contact person: Jessica

1. Product information


Names

Nameliothyronine sodium
SynonymMore Synonyms

 3,3'',5-Triiodo-L-thyronine Sodium Salt Biological Activity

Description3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
Related Catalog
Signaling Pathways >> Others >> Thyroid Hormone Receptor
Research Areas >> Cancer
Research Areas >> Endocrinology
Target

TRβ1[1][2]

In Vitro3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2].
Cell AssayThyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × 104 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].
References

[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

 Chemical & Physical Properties

Boiling Point563.5oC at 760 mmHg
Melting Point205 °C (dec.)(lit.)
Molecular FormulaC15H11I3NNaO4
Molecular Weight672.955
Flash Point294.6oC
Exact Mass672.771973
PSA95.61000
LogP3.31830



2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


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3. Shipping

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4. Contact information

For more details, pls contact us freely.

Mob: 86 17630978909

WhatsApp/Skype/Wechat/LINE: 86 17630978909

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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