Product Details
| Product Name:
Linvencorvir |
CAS No.:
1808248-05-6 |
| Purity:
99.79% |
Supply Ability:
10g |
| Release date:
2024/11/09 |
Product Introduction
Bioactivity
| 名稱 | Linvencorvir |
| 描述 | Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection. |
| 體內(nèi)活性 | Linvencorvir (RO7049389) (600/1000?mg; oral; Caucasian and Asian, male and female) followed by 100?μg intravenous [13 C]RO7049389. The model performance in predicting the pharmacokinetic profiles of RO7049389 aligned with clinical observations in Caucasians and was also successfully applied to Asians. Accordingly, the drug disposition pathways for RO7049389 were postulated with newly characterized estimates of the fractions: biliary excretion by P-glycoprotein (~41%), direct glucuronidation via uridine 5'-diphosphoglucuronosyltransferase 1A3 (~11%), hexose conjugation (~6%), oxidation by CYP3A4 (~28%) and other oxidation reactions (~9%). These results support the ongoing clinical development program for RO7049389 and highlight the broader value of PBPK and MB analyses in drug development.[3] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (100.22 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Linvencorvir | RG-7907 | RG 7907 |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Rifampicin | Ampicillin sodium | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Spectinomycin dihydrochloride | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt | Gentamicin sulfate |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States