Leonurine hydrochloride NEW
| Price | $31 | $48 | $106 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Leonurine hydrochloride | CAS No.: 24735-18-0 |
| Purity: 99.47% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Leonurine hydrochloride |
| 描述 | Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles. |
| 體外活性 | The treatment of Leonurine hydrochloride (10-50?μM) for 24?h increases apoptotic ratio from 4.9% to 11.5-61.3%, respectively. The inhibition effect of Leonurine hydrochloride on H292 cells is related to the generation of ROS and the loss of MMP. Leonurine hydrochloride can increase the phosphorylation level of p38 and reduce Akt phosphorylation. Furthermore, Leonurine hydrochloride treatment increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2[1]. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppresses RANKL-induced osteoclastogenesis and actin ring formation in a dose-dependent manner [2]. |
| 體內(nèi)活性 | Leonurine hydrochloride can elevate the ET level and ET/NO ratio in rats with up-regulated ETA mRNA expression and induced abortions, but there is no change in ETB mRNA[3]. Compared with the model group, Leonurine hydrochloride treatment markedly reduces the volume of bleeding and intrauterine residual, and markedly shortens the duration of bleeding. Leonurine hydrochloride also obviously reinforces the tension and frequency of uterine contractions [4]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : < 1 mg/mL (insoluble） |
| 關(guān)鍵字 | SCM198 | SCM-198 | inhibit | Inhibitor | Autophagy | SCM-198 Hydrochloride | Leonurine Hydrochloride | Leonurine hydrochloride | SCM 198 | SCM198 Hydrochloride | Leonurine | SCM 198 Hydrochloride |
| 相關(guān)產(chǎn)品 | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Paeonol | Naringin | Gefitinib |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 生物堿類天然產(chǎn)物庫 | 自噬庫 | 中藥抗炎分子庫 | 天然產(chǎn)物庫 | 活血化瘀中藥單體庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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