LDN-212320 NEW
| Price | $39 | $64 | $98 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: LDN-212320 | CAS No.: 894002-50-7 |
| Purity: 98.13% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | LDN-212320 |
| Description | LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. |
| In vitro | LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining [2]. |
| In vivo | After LDN/OSU-0212320(a single i.p.; 40-mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 16.67 mg/mL (56.81 mM), Sonication is recommended. |
| Keywords | Glutamate transporter 1 | LDN-212320 | inhibit | EAAT2 | LDN/OSU 0212320 | LDN/OSU0212320 | LDN 0212320 | Inhibitor | LDN 212320 | OSU 0212320 | OSU0212320 | LDN0212320 | GLT-1 | Excitatory amino acid transporter 2 | LDN212320 |
| Inhibitors Related | MSNBA | Fraxin | Venuloside A | Brilliant Yellow | WAY-213613 hydrochloride | Jujuboside A | IPN60090 | SLC26A3-IN-1 | BAY-876 | Phloretin | GT 949 | Telaglenastat |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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