Lamotrigine hydrate NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Lamotrigine hydrate | CAS No.: 375347-20-9 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Lamotrigine hydrate |
| Description | Lamotrigine hydrate is an effective oral active anticonvulsant or antiepileptic agent that selectively blocks voltage-gated Na + channels, stabilizes presynaptic neuronal membranes and inhibits glutamate release. Lamotrigine hydrate can be used in epilepsy, focal seizure, et al [1] [2]. |
| In vitro | Lamotrigine hydrate effectively inhibits the Veratrine-induced release of glutamate and aspartate, displaying equal potency with ED50 values of 21 μM for both amino acids. However, its efficacy in reducing GABA release is notably weaker, with an ED50 of 44 μM. Furthermore, Lamotrigine hydrate demonstrates no impact on potassium-evoked amino acid release at concentrations up to 300 μM. Additionally, it is significantly less potent—approximately fivefold—in inhibiting the release of [3H]acetylcholine evoked by Veratrine, with an ED50 of 100 μM, compared to its effect on glutamate or aspartate release. |
| In vivo | Lamotrigine hydrate, administered intraperitoneally (IP) 30 minutes prior to pentylenetetrazol at doses of 10 mg/kg, 15 mg/kg, or 20 mg/kg, reduces seizure intensity at higher concentrations and prolongs the latency period before the onset of the first pentylenetetrazol-induced seizure across all doses, in comparison to control groups [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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