Laduviglusib trihydrochloride NEW
| Price | $36 | $52 | $85 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Laduviglusib trihydrochloride | CAS No.: 1782235-14-6 |
| Purity: 99.03% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Laduviglusib trihydrochloride |
| Description | Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-3β with a Ki of 9.8 nM. Laduviglusib trihydrochloride is an activator of Wnt/β-catenin signaling. Laduviglusib trihydrochloride induces autophagy. |
| In vitro | Laduviglusib trihydrochloride(10 μM) lowers the viability of the ES-D3 cells by 24.7% at 2.5 μM, 56.3% at 5 μM, 61.9% at 7.5 μM and 69.2% with an IC50 of 4.9 μM[2]. Laduviglusib trihydrochloride shows >500-fold selectivity over ERK2, CDC2, and other protein kinases. Laduviglusib trihydrochloride specifically inhibits GSK3β and GSK3α with IC50s of 5nM and 10nM in vitro kinase assays[4]. |
| In vivo | Oral administration of Laduviglusib trihydrochloride(16 mg/kg and 48 mg/kg) rapidly reduces plasma glucose with a maximal reduction of nearly 150 mg/dl in ZDF rats[1]. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride (2 mg/kg) improves survival after 14.5 Gy abdominal irradiation. Laduviglusib trihydrochloride inhibits crypt apoptosis and accumulation of p-H2AX+ cells, and improves crypt regeneration and villus height. Laduviglusib trihydrochloride blocks apoptosis, increases Lgr5+ cell survival and prevents the reduction of Olfm4, Lgr5 and CD44[5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 17.1 mg/mL (29.8 mM), Sonication and heating are recommended. DMSO : 28.8 mg/mL (50.1 mM) |
| Keywords | 252917-06-9 free base | CHIR 99021 Trihydrochloride | Laduviglusib | CHIR99021 Trihydrochloride | CT99021 Trihydrochloride | CT-99021 Trihydrochloride | CT 99021 Trihydrochloride | CT99021 | CHIR 99021 | 252917-06-9 | CHIR99021 | CHIR-99021 | CHIR-99021 Trihydrochloride | CT-99021 | Laduviglusib Trihydrochloride | CT 99021 |
| Inhibitors Related | Urea | Cromolyn sodium | Wnt pathway activator 1 | GSK 3 Inhibitor IX | CHIR-99021 | AT7519 | 4-Chloro-2'-bromoacetophenone | XAV-939 | SNS-032 | GSK-3 Inhibitor 5 | Nefopam hydrochloride | Bisdemethoxycurcumin |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Neuroprotective Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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