L-Leucyl-L-Leucine methyl ester hydrochloride NEW
| Price | $41 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-20 |
Product Details
| Product Name: L-Leucyl-L-Leucine methyl ester hydrochloride | CAS No.: 6491-83-4 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/20 |
Product Introduction
Bioactivity
| Name | L-Leucyl-L-Leucine methyl ester hydrochloride |
| Description | L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) is a dipeptide condensation product of L-leucine methyl ester produced by human monocytes or polymorphonuclear leukocytes. L-Leucyl-L-Leucine methyl ester hydrochloride selectively eliminates lymphocytes with cytotoxic potential and also induces lysosomal stress. |
| In vitro | METHODS: hSMCs cells were treated with GW 7647 (100-600 nM) for 24-96 h. DNA content was determined. RESULTS: GW 7647 treatment inhibited proliferation in a dose-dependent manner. [1] METHODS: Gastric sinus mucosa was treated with GW 7647 (50 nM) for 10 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: In gastric sinus mucosa, GW 7647 stimulated PI3K phosphorylation followed by Akt (Ser473) phosphorylation, which induced NOS1 phosphorylation. [2] |
| In vivo | METHODS: To investigate the improvement of AD model and the mechanism, GW7647 (2.5 mg/kg) was administered to APP/PS1 transgenic mice daily for three months. RESULTS: GW 7647 reduced the Aβ burden and ameliorated cognitive deficits in APP/PS1 mice, and activation of PPAR-α by GW 7647 ameliorated the disruption of iron homeostasis and attenuated neuronal inflammation and lipid peroxidation in the brains of APP/PS1 mice, which may be related to the up-regulation of GPx4 transcripts mediated by the interaction between GPx4 non-coding regions and PPAR-α. [3] METHODS: To investigate the effects on hepatocarcinogenesis in mice, GW 7647 (0.01% w/w) was administered dietary to wild-type, Para-null, or PPARA-humanized mice daily for 1, 5, and 26 weeks or chronically. RESULTS: In wild-type mice, GW 7647 caused high rates of hepatic expression of known PPARα target genes, hepatomegaly, hepatic MYC expression, hepatocytotoxicity, and hepatocellular carcinoma. In contrast, these effects were largely absent in Ppara-null mice and attenuated in PPARA-humanized mice, although hepatocarcinogenesis was observed in both genotypes. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 27.5 mg/mL (93.28 mM) |
| Keywords | lymphocytes | L-Leucyl-L-Leucine methyl ester Hydrochloride | leukocytes | monocytes | pathway | Leu-Leu-ome Hydrochloride | LLeucylLLeucine methyl ester hydrochloride | LLOMe | inhibit | polymorphonuclear | stress | Leu-Leu methyl ester | cytotoxic | Inhibitor | L Leucyl L Leucine methyl ester hydrochloride | Endogenous Metabolite | endolysosomal |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Geraniol | Formamide | Oleamide | Glycerol | Thymidine | Naringin | Oxalic acid dihydrate |
| Related Compound Libraries | Bioactive Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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