L-DABA hydrobromide NEW
| Price | $41 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: L-DABA hydrobromide | CAS No.: 73143-97-2 |
| Purity: 99.11% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | L-DABA hydrobromide |
| 描述 | L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders. |
| 體外活性 | Incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C irreversibly and completely damages tumor cells. The cell-destructive effect caused by L-DABA hydrobromide is likely a result of osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. Concomitant incubation with L-alanine and L-methionine can abolish the harmful effect of L-DABA hydrobromide[1]. Kinetic studies indicate that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The elevation of GABA levels induced by L-DABA hydrobromide parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produces a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[2]. |
| 體內(nèi)活性 | Treatment with L-DABA hydrobromide leads to a 43.4% reduction in tumor growth[1]. In vivo, L-DABA hydrobromide more effectively inhibits GABA transaminase than it does in vitro[3]. |
| 存儲條件 | keep away from moisture | Shipping with blue ice. |
| 溶解度 | DMSO : 1.99 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | L-2,4-Diaminobutyric acid Hydrobromide | L-DABA Hydrobromide |
| 相關(guān)產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin | Salicylic acid | Oxalic acid dihydrate |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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