Manufacturer Provide Pharmacetical Raw Materials CAS151533-22-1 L-5-Methyltetrahydrofolate Calcium

Introduction

1.Product Name:  L-5-Methyltetrahydrofolate Calcium

2.Other name :Levomefolate calcium

3.CAS NO: 151533-22-1

4.Purity: 99%

5.Appearance: White to Yellow or Beige Powder

6.Molecular formula: C20H27CaN7O6

7.Molecular weight: 501.56

8.MeltingPoint :>300°C

9.Solubility: Acid solution (heated), water (slightly dissolved, heated)

L-5-MTHF-Ca (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. 5-mthf is also known as levomethyl-folate, which is the most biologically active and functional of folic acid. Form, more easily absorbed than ordinary folic acid. Common folic acid must be converted to type 1 methyl folate to participate in two major metabolic pathways: methylation and DNA synthesis, the only form of free folate normally present in human plasma and cells is 5-mthf. Lack of folic acid is usually caused by vitamin deficiency, which is insufficient for absorption. During pregnancy and breastfeeding, the need for folic acid is increased during the growth of children.
Application Area:
1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
3. as adjuvant therapy for colon cancer, rectal cancer
4. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
5. For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.