Product Details
| Product Name:
KY02111 |
CAS No.:
1118807-13-8 |
| Purity:
98.68% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | KY02111 |
| 描述 | KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC. |
| 體內(nèi)活性 | When applied to human embryonic stem cell lines (hESC; KhES-1 and KhES-3), human-induced pluripotent stem cell lines (hiPSC; 253G1, IMR90-1, IMR90-4, and RCHIPC0003), and a mouse embryonic stem cell line (R1), KY02111 (10 μM) significantly increases the proportion of cardiomyocytes by 70%-94%. In IMR90-1 hiPSCs, KY02111 (10 μM) downregulates the expression of 72.7% of target genes in the WNT signaling pathway. Furthermore, in TOPflash assays, a dose-dependent decrease in luciferase reporter activity was observed when KY02111 (10 μM) was applied to HEK293 and IMR90-1 hiPSC cells, indicating a suppression of WNT/β-catenin signaling. Remarkably, doses of KY02111 ranging from 10 μM to 25 μM enhanced cardiac differentiation in transgenic monkey ESCs approximately 80-fold compared to the control group, without exhibiting cytotoxicity at high concentrations. In SW480 cells, KY02111 (10 μM) also significantly reduced luciferase activity in TOPflash assays, highlighting its ineffectiveness against XAV939 and IWP-2. However, KY02111 notably diminished the luciferase activity induced by the GSK3β inhibitor BIO in SW480 cells, outperforming the effects of XAV939 and IWP-2. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 18.8 mg/mL (50 mM)
|
| 關(guān)鍵字 | Inhibitor | differentiation | stem | pluripotent | KY-02111 | cardiomyocyte | cells | cardiac | inhibit | regeneration | of human | Wnt | KY 02111 | KY02111 |
| 相關(guān)產(chǎn)品 | Urea | PRI-724 | Wnt pathway activator 1 | L-quebrachitol | MSAB | EMT inhibitor-1 | Wogonin | CHIR-99021 | XAV-939 | Nefopam hydrochloride | KY-05009 | Bisdemethoxycurcumin |
| 相關(guān)庫 | 細(xì)胞重編程化合物庫 | 神經(jīng)再生化合物庫 | 經(jīng)典已知活性庫 | 癌細(xì)胞分化化合物庫 | 抗肥胖化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 神經(jīng)元分化化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP7Y
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Career Henan Chemical Co
|
2019-09-05 |
United States