Product Details
| Product Name:
KD-3010 |
CAS No.:
934760-92-6 |
| Purity:
99.61% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | KD-3010 |
| Description | KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury. |
| In vivo | To investigate the potential benefits of PPARδ agonists in experimental liver fibrosis, mice are orally treated with a PPARδ agonist, KD-3010, or the well-validated PPARδ agonist GW501516. In liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL), KD-3010, but not GW501516, demonstrates hepatoprotective and antifibrotic effects. The induction of liver injury is achieved through repeated injections of CCl4, and mice are orally administered vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 on a daily basis. Control mice injected with oil do not exhibit liver damage. Liver injury, characterized by hepatocyte death and inflammation, is observed in the group treated with vehicle or GW501516 and injected with CCl4 based on H&E-stained liver sections, but this injury is markedly reduced in the KD-3010-treated group[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | KD 3010 | KD3010 | KD-3010 |
| Inhibitors Related | PHYTOL | (S)-(+)-Ibuprofen | BADGE | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$74.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
|
|
$1.80/1KG |
VIP5Y
|
Career Henan Chemica Co
|
2020-11-11 |
United States