JNJ-54166060 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: JNJ-54166060 | CAS No.: 1627900-41-7 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | JNJ-54166060 |
| Description | JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50 values of 4 nM, 115 nM, and 72 nM for the human, rat, and mouse P2X7 receptors, respectively [1]. |
| In vivo | JNJ-54166060 demonstrates significant effectiveness across various animal models, with high oral bioavailability observed in rats (55%), dogs (>100%), and monkeys (54%), alongside considerable maximum plasma concentrations (C max) of 375 ng/mL, 1249 ng/mL, and 389 ng/mL, respectively, following a 5 mg/kg oral dose. Intravenously administered at 1 mg/kg, the compound showed low to moderate clearance rates, resulting in terminal elimination half-lives of 1.7 hours in rats, 11.9 hours in dogs, and 4.2 hours in monkeys. These pharmacokinetic parameters indicate the compound's potent and durable presence in systemic circulation across different species, underscoring its potential for further therapeutic development. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | JNJ 54166060 | JNJ-54166060 | JNJ54166060 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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