Product Details
Product Name:
J-104871 |
CAS No.:
191088-19-4 |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | J-104871 |
Description | J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
In vitro | J 104871 inhibits Ras processing in H-ras-transformed NIH3T3 cells with an IC50 value of 3.1 μM and shows minimal inhibition of rat brain protein geranylgeranyltransferase-I or squalene synthase (SS)[1]. |
In vivo | n female nude mice (8 weeks old) injected with activated H-ras-transformed NIH3T3 cells, J 104871 (40 mg/kg, 80 mg/kg; intraperitoneal injection; once daily; 6 days) suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells[1]. |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Keywords | J-104871 |
Inhibitors Related | Ketoconazole | MRTX1133 | CASIN | Sotorasib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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