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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antifungal Drugs>Itraconazole
Itraconazole
  • Itraconazole
  • Itraconazole
  • Itraconazole
  • Itraconazole
  • Itraconazole

Itraconazole NEW

Price Get Latest Price
Package 1KG 25KG
Min. Order: 25KG
Supply Ability: 20tons
Update Time: 2024-10-25

Product Details

Product Name: Itraconazole CAS No.: 84625-61-6
EC-No.: 617-596-9 Min. Order: 25KG
Purity: 0.99 Supply Ability: 20tons
Release date: 2024/10/25

Chemical properties: 

Crystallized from toluene, melting point 166.2℃. pKa3.7. Rarely soluble in water and dilute acid solutions. Acute toxicity LD50(14 days) in mice, rats, dogs (mg/kg) : > 320, > 320, > 200 orally.

Use: 

Imidazole antifungal drug of triazole ring. By preventing the activation of cytochrome P-450 including oxidase and peroxidase, so that 14, α-methylsterol can not dehydrogenate, can not be converted into ergosterol, so that the growth and proliferation of fungi is inhibited, has a strong lipophilic, can pass through the biofilm, inhibit the membrane and fungal binding. Its antibacterial profile is similar to ketoconazole. It is effective for superficial fungal diseases such as vaginal and oral candidiasis and dermatomycosis, and is expected to become an efficient and safe drug for deep fungal infections such as cryptococcal encephalitis (AIDS). It is used for vulvovaginal candidiasis, pityriasis variegata and cutaneous mycosis caused by sensitive fungi.

Production method: 

Starting from m-dichlorobenzene, compound (I) can be obtained by a reaction exactly similar to ketoconazole. Compound (I) is then condensed with 1-acetyl -4-(4-hydroxyphenyl) piperazine, followed by water deacetylation, condensation with p-nitrochlorobenzene, hydroreduction, chlorocarbonate acylation, and then reaction with hydrazine hydrate and recyclization, alkylated to itraconazole

Melting Point

166°C

Specific Rotation

-0.1+0.1°(D/20)(c=10,CH2Cl2)

Density

1.27 g/cm3

Storage Condition

2-8°C

Solubility

Chloroform: 50 mg/mL, clear, colorless

Flashing Point

>110°(230°F)

Merck

14.5245

Boiling Point

850.0±75.0 °C

Article illustration

Article illustration

Company Profile Introduction

Hebei Yanxi Chemical Co. LTD., mainly produce the Carbomer940/980/u21 and lead acetate and lead oxide, lead stearate, lead salt, at the same time operating organic intermediates, surfactants, Food additive,inorganic salt, plant extracts, cosmetics raw material, etc., through long-term development, hebei said bush chemical co., LTD. In hebei province has become a collection of r &d, production, sales in the integration of high-tech enterprises.

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  • Since: 2020-05-25
  • Address: Zhanggeji Village, Fengjiazhai Town, Guangzong County, Xingtai City, Hebei Province
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