Product Details
| Product Name:
ISA-2011B |
CAS No.:
1395347-24-6 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | ISA-2011B |
| 描述 | ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies. |
| 體外活性 | ISA-2011B significantly decreases AR-V7 and CDK1 levels in both the nucleus and cytoplasm of 22Rv1 cells, demonstrating strong binding affinity towards PIP5K1α and both MARK1 and MARK4 among 460 kinases. In PC-3 cells, ISA-2011B treatment reduces PIP5K1α expression by 78.6%[1] and eliminates nuclear AR expression without affecting cytoplasmic AR[2]. Additionally, ISA-2011B markedly lowers the proliferation rates of PC-3 cells to 58.77%, 48.65%, and 21.62% at doses of 10, 20, and 50 μM, respectively, compared to controls. |
| 體內(nèi)活性 | Overexpression of AR-V7 enhances PIP5K1α levels, accelerating prostate cancer (PCa) growth in xenograft mice. Conversely, the PIP5K1α inhibitor ISA-2011B significantly curtails the proliferation and invasiveness of AR-V7 overexpressing xenograft tumors. ISA-2011B effectively impedes tumor cell growth in xenograft mice by targeting the PIP5K1α-related PI3K/AKT pathways, including those responsible for survival, proliferation, and invasion[1]. Furthermore, ISA-2011B interferes with AR-V7 protein stabilization through its dependency on PIP5K1α, thereby hindering the aggressive growth of AR-V7-high tumors in xenograft models[2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 100 mg/mL (235.93 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Inhibitor | ISA-2011B | inhibit | ISA 2011B | ISA2011B |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$66.00/1 PCS |
|
Amikon Limited
|
2019-01-04 |
United States