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IPAG NEW

Price	$38	$89	$139
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: IPAG	CAS No.: 193527-91-2
Purity: 98.8%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	IPAG
Description	IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.
In vitro	IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1[2]. Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells[3].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 7.5 mg/mL (19.0 mM), when pH is adjusted to 3 with 1 M HCl. Sonication and heating to 60℃ are recommended. Ethanol : 50 mMmg
Keywords	IPAG
Inhibitors Related	Docusate sodium \| Bevenopran \| Mirtazapine \| Sinomenine \| (-)-Menthol \| Matrine \| SCH 221510 \| Progesterone \| Naltrexone hydrochloride \| Trimebutine \| Mianserin hydrochloride \| Amentoflavone
Related Compound Libraries	Bioactive Compound Library \| Pain-Related Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Bioactive Compounds Library Max \| GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.