Inositol Nicotinate is known as hexanicotinate-cis-1, 2, 3, 5-trans-4, 6-cyclohexane, also known as inositol nicotinate, nicotinate, inositol hexanicotinate, Xuanxitong injection, etc. It has the effect of lowering cholesterol and dilating peripheral blood vessels, and can be used to treat hypercholesterolemia and atherosclerosis. Clinically, it is used for the adjuvant treatment of hyperlipidemia, coronary heart disease, various peripheral vascular disorders (such as obliterative arteriosclerosis, acroarterial spasm, frostbite, vascular migraine, etc.).

Pharmacological action

After absorption from the gastrointestinal tract, the drug is slowly metabolized in the body, gradually hydrolyzing into niacin and inositol, and then acting through both. It can gently and sustainably dilate peripheral blood vessels, improve abnormal lipid metabolism, dissolve fibrin, dissolve thrombosis and anticoagulation. The indication of hyperlipoproteinemia is the same as niacin, which can be used as adjuvant therapy. And can be used for coronary heart disease and a variety of peripheral vascular spasmodic diseases (such as occlusive arteriosclerosis, acroarterial spasm, migraine, etc.) adjuvant treatment.

Clinical application

Inositol Nicotinate is a mild peripheral vasodilator, which has the effect of lowering cholesterol and dilating peripheral blood vessels, and is an adjunct drug and nutritional food additive for hypercholesterolemia and atherosclerosis. Inositol nicotinate is gradually hydrolyzed to niacin and inositol in vivo, so it has pharmacological effects of both niacin and inositol. Inositol nicotinate has a lipid-lowering effect, and its vasodilating effect is more moderate and long-lasting than niacin, without the side effects of taking niacin such as flushing and stomach upset.

Application:

1 Hypolipidemic drug, has the effect of lowering cholesterol and dilating non-peripheral blood vessels.

2 Biochemical research.