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Postion:Product Catalog >INF 195
INF 195
  • INF 195

INF 195 NEW

Price $74 $116 $232
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: INF 195 CAS No.: 1211379-56-4
Supply Ability: 10g Release date: 2024/11/07

Product Introduction

Bioactivity

名稱INF 195
描述INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction.
體外活性INF 195 (0.1-100 μM, 72 hours) was able to inhibit macrophage pyroptosis and IL-1β release driven by NLRP3. At lower doses (5-10 μM, 10 min), INF 195 was able to reduce the infarct zone in isolated mouse hearts and effectively prevented myocardial ischemia/reperfusion injury.INF 195 (10 μM), as an ethyl ester precursor of the active metabolite 3-(3-(2-chlorophenyl)propanoyl)piperidine-1-carboxylic acid, was able to penetrate into H9c2 cardiomyoblasts, and hydrolyzed intracellularly to this active form. [1]
存儲條件store at low temperature | store at -20°C | Shipping with blue ice.
溶解度DMSO : 150 mg/mL (463.23 mM), Sonication is recommended.
相關(guān)產(chǎn)品Dapansutrile | NOD-IN-1 | CY-09 | MCC950 sodium | Imperatorin | NLRP3-IN-10 | NLRP3-IN-2 | Bergenin | Nigericin sodium salt | NLRP3-IN-9 | INF39 | Selnoflast

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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