Product Details
Product Name:
Inavolisib |
CAS No.:
2060571-02-8 |
Purity:
99.75% |
Supply Ability:
10g |
Release date:
2024/11/13 |
Product Introduction
Bioactivity
名稱 | Inavolisib |
描述 | Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.It exerts its activity by binding to the ATP-binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. |
體外活性 | METHODS: Cell viability was assayed using Inavolisib (GDC-00777) up to 100 μmol/L in a panel of cancer cell lines.
RESULTS Inavolisib (GDC-00777) is a stronger cellular antiproliferative inducer. [1] |
體內活性 | METHODS: p110a protein depletion was studied in a p110a mutant xenograft breast cancer model using Inavolisib (GDC-0077) at a single oral dose of 50 mg/kgDC-0077.
RESULTS Inavolisib (GDC-0077) depleted p110a protein expression for up to 8 hours. [1] |
存儲條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 100 mg/mL (245.48 mM), Sonication is recommended.
|
關鍵字 | Apoptosis | GDC0077 | Phosphoinositide 3-kinase | Inhibitor | PI3K | Inavolisib | RG-6114 | GDC 0077 | inhibit | RG 6114 |
相關產品 | Stavudine | Sodium 4-phenylbutyrate | Tributyrin |
相關庫 | 經典已知活性庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:496-16-2
$29.00 / 1mL
-
CAS:55-10-7
$39.00 / 25mg
-
CAS:138801-72-6
$195.00 / 1mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$0.00/10mg |
VIP1Y
|
Hubei Chuchang Biotech Co., Ltd.
|
2024-03-29 |