Imperatorin NEW
| Price | $41 | $66 | $97 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Imperatorin | CAS No.: 482-44-0 |
| Purity: 99.49% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Imperatorin |
| 描述 | Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. |
| 體外活性 | Imperatorin, a furanocoumarin plant secondary metabolite, enhances GABA-induced chloride ion current (IGABA) via α1β2γ2S receptors, potentiating IGABA at 100 μmol by 50.5±16.3% and at 300 μmol by 109.8±37.7%. Found in A. dahurica roots alongside Phellopterin, Imperatorin inhibits [3H]diazepam binding to the rat brain GABAA receptor benzodiazepine site in vitro, with IC50 values of 12.3 μmol and 400 nmol, respectively. At concentrations of 3.5 to 14 mmol, Imperatorin significantly and irreversibly inhibits GABA-T in a time- and concentration-dependent manner. It also acts as a dose-dependent, reversible acetylcholinesterase (AChE) inhibitor and shows low AChE inhibition (13.75-46.11%) but significant butyrylcholinesterase (BChE) inhibition (37.46-83.98%) with an IC50 of 31.4 μmol. Imperatorin, along with (+)-Byakangelicol, is a potent BACE-1 inhibitor with IC50 values of 91.8 μmol and 104.9 μmol, respectively, and acts as an inhibitor of NO synthesis (IC50=9.2 μmol). Additionally, Imperatorin is a weak agonist of TRPV1, exhibiting an EC50 of 12.6±3.2 μM. |
| 體內(nèi)活性 | Administered at doses of 10 and 20 mg/kg and observed 30 minutes post-injection, Imperatorin demonstrates anxiolytic properties alongside enhancements in memory and learning stages, both acquisition and consolidation. Furthermore, at these dosages, Imperatorin acutely mitigates the anxiety-inducing effects of nicotine (0.1 mg/kg, subcutaneous, s.c.). At increased doses of 30 and 40 mg/kg, intraperitoneally, Imperatorin notably augments the anticonvulsant efficacy of carbamazepine against maximal electroshock-induced seizures, evidenced by a substantial reduction in the effective dose 50 (ED50) of carbamazepine from 10.8 to 6.8 mg/kg (by 34%) and to 6 mg/kg (by 42%), respectively. Additionally, a combination of Imperatorin at 30 mg/kg and carbamazepine at 6.8 mg/kg elevates the total brain concentration of carbamazepine from 1.260 to 2.328 μg/mL (by 85%), potentially through alterations in blood-brain barrier permeability or as an inhibitor of multi-drug resistance proteins. As a naturally occurring furanocoumarin, Imperatorin deactivates gamma-aminobutyric acid transaminase and hinders acetylcholinesterase activity. When administered acutely in doses of 5 and 10 mg/kg prior to scopolamine (1 mg/kg), it counters the memory acquisition and consolidation impairments induced by scopolamine. Repeated administration (7 days, twice daily) of Imperatorin at the highest studied dose (10 mg/kg) significantly diminishes scopolamine’s adverse effects on memory acquisition, with doses of 5 and 10 mg/kg proving effective in memory consolidation. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (203.49 mM) |
| 關(guān)鍵字 | TRP Channel | inhibit | Cholinesterase (ChE) | Inhibitor | Transient receptor potential channels | Imperatorin |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Nanofin | Ribavirin | 4-Methylbenzylidene camphor | Camphor | Diethyltoluamide | 1,4-Cineole | trans-Cinnamaldehyde | Choline chloride | Propoxur | Methyl tridecanoate | Trimethylammonium chloride |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 天然產(chǎn)物庫 | 中藥抗炎分子庫 | 古代經(jīng)典名方目錄分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $2.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-07 | |
| $0.00/20mg |
Shanghai Standard Technology Co., Ltd.
|
2019-10-12 | ||
| $15.00/20mg |
NanJing Spring & Autumn Biological Engineering CO., LTD.
|
2019-07-09 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 | ||
| $0.00/20mg |
Shanghai Standard Technology Co., Ltd.
|
2019-10-12 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-26 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY