Imipramine HCl
Price | Get Latest Price |
Package | 200kg |
Min. Order: | 20kg |
Supply Ability: | 20 tons |
Update Time: | 2024-11-12 |
Product Details
Product Name: Imipramine HCl | CAS No.: 113-52-0 |
Min. Order: 20kg | Purity: 99% |
Supply Ability: 20 tons | Release date: 2024/11/12 |
113-52-0 - Physico-chemical Properties
Molecular Formula | C19H25ClN2 |
Molar Mass | 316.87 |
Melting Point | 168-1700C |
Boling Point | 377.7°C at 760 mmHg |
Flash Point | 9℃ |
Water Solubility | Soluble in water |
Solubility | H2O: 50mg/mL |
Vapor Presure | 6.6E-06mmHg at 25°C |
Appearance | crystalline |
Color | white |
Maximum wavelength(λmax) | ['260nm(lit.)'] |
Merck | 14,4920 |
PH | 4.2~5.2(100g/l,25℃) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | White crystalline powder. Melting Point 174-175 °c. Soluble in water, ethanol, acetone-soluble, almost insoluble in ether. Odorless and bitter. It was gradually changed in light. Imipramine base ([50-49-7]) has a boiling point of 160 °c (13.3). |
Use | For the treatment of various types of depression, infantile enuresis |
In vitro study | Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter. |
In vivo study | Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor. |
Company Profile Introduction
Qingdao RENAS Polymer Material Co., Ltd. is located in E.T.D.Z of Qingdao China, it is one integrated company, devoted to environmental protection and low carbon energy, new materials introducing, research and development, which aims to offer the best quality products and service to the domestic and foreign markets. We maintain a good partnership with many word famous chemical manufacturers. Integrated of advanced products and technology of domestic and foreign manufacturers, we could customize the products matching scheme for various industries customers, and offer the comprehensive solution to customers.
We have unique technology and product advantages, especial in the field of rubber additive, acrylic monomer, solvent, pharmaceutical intermediates and ink coating resin.
We have a professional management, business and technical team, and have passed the ISO9001 system certification. We have passed the fast response ability and reliable product quality. With the mission of "steady development and dedication to China", we adhere to the business philosophy of "the interests of users are our most fundamental interests, and the needs of users are our needs". Through concept innovation, management innovation, technical innovation, market innovation, and product innovation, Strive to make the company an excellent supplier in the field of global chemical materials.
We welcome friends all over the world to visit and negotiate with us. We sincerely hope to expand our trade and cooperation based on mutual benefits and realize the mutual prosperity and development.
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- Since: 2010-04-27
- Address: No. 18 Qinhuangdao Road, E.T.D.Z of QINGDAO
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