Ifenprodil Tartrate NEW
| Price | $50 | $65 | $108 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Ifenprodil Tartrate | CAS No.: 23210-58-4 |
| Purity: 99.7% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Ifenprodil Tartrate |
| 描述 | Ifenprodil is a selective NMDA receptor (glutamate) antagonist. |
| 激酶實(shí)驗(yàn) | In vitro biochemical and pharmacological assaysinhibition studies with recombinant human COX-1 and COX-2: Microsomal preparations of recombinant human COX-1 and COX-2 are prepared from a vaccinia virus-COS-7 cell expression system. Recombinant human COX-1 and COX-2 are expressed in baculovirus-Sf9 cells, and enzymes are purified. Enzymatic activity is monitored continuously by either a fluorescence assay measuring the appearance of the oxidized form of the reducing agent cosubstrate homovanillic acid or by oxygen consumption. The HPLC assay for the assessment of inhibition of purified COX-1 by Rofecoxib with 0.1 μM arachidonic acid substrate concentration, the determination of the stoichiometry of the complex between COX-2 and Rofecoxib, the dissociation rate constant of the enzyme-inhibitor complex by recovery of enzymatic activity, and the recovery of intact Rofecoxib from that complex are all performed as described previously. The solvent system for the HPLC analysis of Rofecoxib is 15:85 MeOH/aqueous potassium phosphate (1 g/liter), with elution by a linear gradient of 15 to 75% MeOH over 25 minutes with detection at 275 nm on a Novapak C18 column. |
| 體內(nèi)活性 | Ifenprodil inhibits NMDA-induced currents at both 10 μM and 100 μM, with IC50 values of 0.88 μM and 0.17 μM, respectively. In rat cortical neurons, Ifenprodil (10 μM) suppresses the majority of currents elicited by NMDA receptors. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (112.36 mM) Ethanol : 58 mg/mL (107.7 mM) H2O : 9 mg/mL (11.23 mM) |
| 關(guān)鍵字 | KcsA | inhibit | Ifenprodil Tartrate | vasodilator | iGluR | current | Ionotropic glutamate receptors | Ifenprodil | NR1A | Inhibitor | NMDA | Potassium Channel | cerebral | NR2B |
| 相關(guān)產(chǎn)品 | Minoxidil sulfate | L-Glutamic acid | glycine | Halothane | L-Glutamic acid monosodium salt | Riluzole | Cloperastine hydrochloride | O-Phospho-L-serine | Indapamide |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 藥物功能重定位化合物庫(kù) | 抗病毒庫(kù) | 神經(jīng)保護(hù)化合物庫(kù) | 抗癌上市藥物庫(kù) | 已知活性化合物庫(kù) | 離子通道庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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