Hydroxyfasudil Hydrochloride NEW
| Price | $55 | $84 | $127 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Hydroxyfasudil Hydrochloride | CAS No.: 155558-32-0 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Hydroxyfasudil Hydrochloride |
| 描述 | Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
| 動物實驗 | Hydroxyfasudil is formulated in saline.Micturition behavior is studied after administration of either Hydroxyfasudil (10 mg/kg, i.p.) or a corresponding volume of saline. Each rat is placed in a metabolic cage containing a urine collection funnel that is placed over an electronic balance. The balance is connected to a personal computer via a multiport controller and used to measure the cumulative weight of the collected urine. Every 150 s during a continuous 24-h period, the computer samples and records the data for the micturition frequency and volumes. The micturition reflex parameters that are collected include: urine volume per micturition, maximal micturition volume, micturition frequency, and total urine output in the Hydroxyfasudil- or vehicle-treated animals. Each monitoring session started at 18.00 hours. Prior to being placed in the metabolic cage at the start of each experimental period, the animals received either a single injection of Hydroxyfasudil (10 mg/kg) dissolved in saline or an injection of saline without the inhibitor. |
| 體外活性 | Hydroxyfasudil has a weak inhibition of PKA (IC50: 37 μM), 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels (EC50: 0.8 ± 0.3 μM). Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in HAEC. Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours but does not affect eNOS promoter activity (0.1-100 μM). |
| 體內(nèi)活性 | Hydroxyfasudil (10 mg/kg, i.p.) markedly increases both the maximal and average voided volumes and reduces maximal detrusor pressure in SD rats. In spontaneously hypertensive rats (SHRs), Hydroxyfasudil (3 mg/kg, i.p.) inhibits norepinephrine-induced hypercontractility and significantly ameliorates decreased penile cGMP contents at doses of 3/10 mg/kg, i.p. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 62 mg/mL (180.3 mM) |
| 關鍵字 | HA-1100 | ROCK | Rho-associated kinase | HA 1100 | inhibit | HA1100 | HA1100 Hydrochloride | Rho-kinase | Rho-associated protein kinase | HA-1100 Hydrochloride | ROK | Inhibitor | HA 1100 Hydrochloride | Hydroxyfasudil | Hydroxyfasudil Hydrochloride |
| 相關產(chǎn)品 | GSK180736A | SAR407899 hydrochloride | RKI-1447 | Belumosudil | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | Y-27632 | ROCK-IN-5 | Thiazovivin |
| 相關庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | 干細胞分化化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 細胞周期化合物庫 | 抗代謝疾病化合物庫 | 抗癌化合物庫 | TGF-β/Smad靶點化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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