ChemicalBook CAS DataBase List 2-Chlorobenzoic acid

2-Chlorobenzoic acid synthesis

13synthesis methods

Product Name:2-Chlorobenzoic acid
CAS Number:118-91-2
Molecular formula:C7H5ClO2
Molecular Weight:156.57

It is prepared by the oxidation of 2-chlorotoluene. The laboratory scale reaction employs potassium permanganate. Alternatively it arises by the hydrolysis of α,α,α-trichloro-2-toluene.
The chloride is readily replaced by ammonia to 2-aminobenzoic acid. At elevated temperature it decarboxylates.

873-32-5 Synthesis

873-32-5
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118-91-2
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Yield:118-91-2 168 g

Reaction Conditions:

with hydrogenchloride in water monomer at 100 - 110;

Steps:

10 Example 10: Preparation of ortho-chloro benzoic acid (IV)

To a mixture of ortho-chloro benzonitrile (250 g) and water (562.5 g), concentrated hydrochloric acid (187.5 g) was added under stirring for 15 to 30 minutes and mixture was heated to 100°C to 110°C for 6 to 8 hours. The reaction mixture was cooled to room temperature and stirred for 1 to 2 hours. The precipitated solid was filtered, washed with water and dried under vacuum to get ortho-chloro benzoic acid compound (168 g, 98%, HPLC purity 99.79%).

References:

WO2022/91014,2022,A1 Location in patent:Page/Page column 12

201230-82-2 Synthesis