Product Details
| Product Name:
H3B-8800 |
CAS No.:
1825302-42-8 |
| Purity:
98.21% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | H3B-8800 |
| Description | H3B-8800 is an SF3B1 modulator that can be used to study transfusion-dependent anemia. |
| In vivo | We conducted a Phase I clinical trial of H3B-8800, an oral small molecule compound that binds splicing factor 3B1 (SF3B1), in patients with MDS, CMML or AML. Of the 84 patients enrolled in the trial (42 MDS, 4 CMML and 38 AML), 62 were dependent on red blood cell (RBC) transfusions at enrollment. The dose-escalation cohort examined two once-daily dosing regimens: regimen I (5 days on/9 days off, study dose range 1-40 mg, n=65) and regimen II (21 days on/7 days off, 7-20 mg, n=19); 27 patients were treated for ≥180 days. The most common treatment-related emergent adverse events included diarrhea, nausea, fatigue, and vomiting. No complete or partial responses meeting IWG criteria were observed; however, RBC transfusion free intervals of more than 56 days were observed in nine patients who were transfusion dependent at enrollment (15%). Five of 15 MDS patients with missense SF3B1 mutations experienced RBC transfusion independence (TI). Increased expression of the pre-treatment target of splicing transmembrane protein 14C (TMEM14C) was observed in MDS patients experiencing RBC TI. |
| Storage | store at low temperature | Shipping with blue ice. |
| Keywords | H3B 8800 | H3B8800 | H3B-8800 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1140.00/25mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States