GW 4064 NEW
| Price | $46 | $76 | $142 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: GW 4064 | CAS No.: 278779-30-9 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | GW 4064 |
| 描述 | GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM). |
| 細胞實驗 | GW 4064 is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Mouse liver cells (BNL CL.2) are maintained in a humidified incubator under 5% CO2 at 37°C in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% Penicillin/Streptomycin. When cells are divided into six-well plates and reach ~90% confluence, sub-confluent cells are washed three times with phosphate buffered saline (PBS) and replaced with serum-free DMEM supplemented with 1% fatty acid-free BSA. Oleic acid (final concentration 500 μM) and GW4064 at various concentrations are added and incubated for 24 h. Cells are then fixed with 4% formaldehyde for Oil Red O staining or harvested for protein and western blot analysis[2]. |
| 體外活性 | In Fisher rats, oral administration of GW 4064 (ED50 = 20 mg/kg) effectively reduces serum triglycerides. |
| 體內(nèi)活性 | In CV-1 cells transfected with mouse FXR expression vectors (EC50=80 nM) and in CV-1 cells transfected with human FXR expression vectors (EC50=90 nM), GW 4064 functions as a selective non-steroidal FXR agonist, effectively exerting agonistic effects. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (92.11 mM) Ethanol : 5.4 mg/mL (10 mM) |
| 關(guān)鍵字 | Inhibitor | FXR | Autophagy | GW 4064 | inhibit | NR1H4 | GW-4064 | GW4064 |
| 相關(guān)產(chǎn)品 | Stavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| 相關(guān)庫 | 核受體化合物庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 自噬庫 | NO PAINS 化合物庫 | 代謝化合物庫 | 脂代謝化合物庫 | 已知活性化合物庫 | 活性脂質(zhì)化合物庫 | 抗代謝疾病化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1G |
VIP1Y
|
CONTIDE BIOTECH CO.,LTD
|
2024-04-12 | |
| $40.00/1Box |
zhuzhou dingcheng meihei comestic co.,ltd
|
2023-12-07 | ||
| $0.00/1kg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-10-13 | |
| $30.00/1kg |
Anhui Ruihan Technology Co., Ltd
|
2023-09-08 | ||
| $1.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2019-12-26 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY