GsMTx4 TFA (1209500-46-8 free base) NEW

Price	$468	$1080	$1450
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-15

Product Details

Product Name: GsMTx4 TFA (1209500-46-8 free base)	Purity: 99.81%
Supply Ability: 10g	Release date: 2024/11/15

Product Introduction

Bioactivity

名稱	GsMTx4 TFA (1209500-46-8 free base)
描述	GsMTx4 TFA (1209500-46-8 free base) is a spider venom peptide that selectively inhibits cation permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
體外活性	METHODS: GsMTx4 TFA (5 μM) was tested on outside-out patches of HEK cells transfected with mouse Piezo1 cDNA. RESULTS GsMTx4 TFA reduced Piezo1-mediated charge transfer to 38% of its initial level. [1] METHODS: Using C57BL/6 mice as samples, organotypic cerebellar slices (OCS) were prepared and treated with Piezo1 specific activator Yoda-1 (10 μM, 48 hours) or Piezo1 peptide inhibitor GsMTx4 (500 nM, 48 hours). Hours) organotypic cerebellar slices were processed to study how activating or blocking Piezo1 affects myelination. RESULTS GsMTx4 TFA may rescue psychotin-induced demyelination. [3] METHODS: MCF10A cells were incubated with adipokines for 24-72 hours. Use GSMTx4 TFA at a concentration of 2.5 μM as a mechanosensitive Ca2+ channel inhibitor for 16 hours. RESULTS GSMTx4 TFA significantly reduced leptin-induced AMPK and MLC-2 phosphorylation. [4]
體內(nèi)活性	METHODS: The effects of blocking the Piezo1/CaN/NFAT1 signaling axis by intra-articular injection of GsMTx4 TFA on ACLT-induced osteoarthritis (OA) rats were studied. Taking into account the rapid clearance of synovial fluid, we performed 7, 14, 21, 28 ACLT + H-Gsmtx4 groups at two different frequencies (once a week in the H-GsMTx4 TFA group and once every two weeks in the L-GsMTx4 TFA group). , 35, 42 and 49 days and ACLT + L-Gsmtx4 group were intra-articularly injected with 100 μL of 40 μM Gsmtx4 TFA on 7, 21, 35 and 49 days after surgery. RESULTS GsMTx4 TFA can improve OA in rats by inhibiting apoptosis and imbalance of anabolism and catabolism. [2]
存儲(chǔ)條件	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 66.66 mg/mL, Sonication is recommended.
關(guān)鍵字	GsMTx4 TFA (1209500468 free base) \| 1209500-46-8 free base \| 1209500-46-8 \| GsMTx4 TFA (1209500 46 8 free base) \| GsMTx-4 TFA (1209500-46-8 free base)
相關(guān)產(chǎn)品	D-GsMTx4 TFA \| Yoda 1
相關(guān)庫(kù)	多肽分子庫(kù) \| NO PAINS 化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.