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Postion:Product Catalog >GSK-626616
GSK-626616
  • GSK-626616

GSK-626616 NEW

Price $44 $97 $155
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: GSK-626616 CAS No.: 1025821-33-3
Purity: 99.48% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱GSK-626616
描述GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.
體外活性GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. GSK-626616 enhances the binding of PRAS40 to mTORC1[2]. GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired[2].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 49 mg/mL (122.11 mM), Sonication is recommended.
關(guān)鍵字DYRK | GSK 626616 | Inhibitor | Dual specificity tyrosine regulated kinase | GSK626616 | inhibit | Dual specificity tyrosine phosphorylation regulated kinase | GSK-626616
相關(guān)產(chǎn)品AZ-Dyrk1B-33 | Harmine | ML 315 | EHT 1610 | ARN25068 | CK2/ERK8-IN-1 | YK-2-69 | AnnH31 | 7BIO | INDY | ML167 | LDN-192960
相關(guān)庫經(jīng)典已知活性庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 細(xì)胞周期化合物庫 | 抗癌藥物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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