GSK-3β inhibitor 2 NEW
| Price | $50 | $67 | $107 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: GSK-3β inhibitor 2 | CAS No.: 1702428-31-6 |
| Purity: 95.69% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | GSK-3β inhibitor 2 |
| 描述 | GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Alzheimer's disease. |
| 體外活性 | The pyridine carboxamide of GSK-3β inhibitor 2 forms hydrogen bonds with the hinge V135 backbone amide, while the carbonyl oxygen of the thiazolyl primary amide establishes a critical hydrogen bond with K85. Single crystal X-ray diffraction confirms intramolecular hydrogen bonding between the methoxy -O- and the amide N-H in GSK-3β inhibitor 2 [1]. |
| 體內(nèi)活性 | In LaFerla 3xTg-C57BL6 mice with Alzheimer’s disease, GSK-3β inhibitor 2 (30 mg/kg; oral) significantly reduces hyperphosphorylated Tau396. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26), determined as a single time point[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5 mg/mL (15.71 mM), Sonication is recommended. |
| 關(guān)鍵字 | GSK-3β inhibitor 2 | GSK-3b inhibitor 2 | GSK-3beta inhibitor 2 |
| 相關(guān)產(chǎn)品 | PHA-767491 | Cromolyn sodium | GSK 3 Inhibitor IX | AT7519 | 5-Bromoindole | 4-Chloro-2'-bromoacetophenone | SNS-032 | GSK-3 Inhibitor 5 | MeBIO | 1-Azakenpaullone |
| 相關(guān)庫 | 抗結(jié)直腸癌化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 抗抑郁癥化合物庫 | 激酶抑制劑庫 | 抑制劑庫 | 神經(jīng)保護化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 神經(jīng)元分化化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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