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Postion:Product Catalog >GRI977143
GRI977143
  • GRI977143

GRI977143 NEW

Price $33 $76 $133
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: GRI977143 CAS No.: 325850-81-5
Purity: 98.07% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱GRI977143
描述GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.
體外活性GRI977143 (10 μM) reduces caspase 3 and 7 activation by 51% in Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. GRI977143 stimulates the activation of extracellular signal-regulated kinase 1/2 and promotes the assembly of LPA2, thyroid receptor-interacting protein 6 and Na+-H+ exchange regulatory factor 2[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 1 mg/ml, Sonication is recommended.
關(guān)鍵字GRI-977143 | GRI977143
相關(guān)產(chǎn)品Radioprotectin-1 | DBIBB | AM966 | H2L 5765834 | Ki16198 | Tetradecyl Phosphonate | LPA2 antagonist 2 | LPA1 receptor antagonist 1 | UCM-05194 | TAK-615 | H2L5186303 | Ki16425
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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