Gossypol (acetic acid) NEW
| Price | $30 | $39 | $64 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Gossypol (acetic acid) | CAS No.: 12542-36-8 |
| Purity: 98.57% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Gossypol (acetic acid) |
| Description | Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID. |
| Cell Research | MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference) |
| In vitro | Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner[1]. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro[2]. |
| In vivo | Gossypol acetate is able to inhibit tumor growth in Wus1-bearing mice, but the survival of mice is not prolonged, and tumor grows rapidly after short inhibition. Gossypol has now been found to have inhibitory effects on proliferation or to induce apoptosis in ovarian cancer, endometrial cancer, adrenal cortical tumor, thyroid cancer, lung cancer, colon carcinoma, leukemia, pancreatic cancer, melanoma and lymphoma. In addition, gossypol can increase the sensitivity of drug-resistant tumor cells to chemotherapy and radiotherapy. Some Clinicalal trials showed gossypol is well-tolerated, and partial responses are observed in some patients[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 100 mg/mL (172.82 mM) Ethanol : 2 mg/mL (3.5 mM) |
| Keywords | acetic acid | inhibit | Gossypol-acetic acid | AT 101 | Inhibitor | AT-101 | Gossypol | BL-193 (acetic acid) | Gossypol (acetic acid) | Bcl-2 Family |
| Inhibitors Related | (S)-(+)-Ibuprofen | Allethrin | SMBA1 | TV 3279 | Rasagiline | Navitoclax | Diphenyl disulfide | Lisaftoclax | UMI-77 | Venetoclax | A-1210477 | (R)-(-)-Gossypol acetic acid |
| Related Compound Libraries | Polyphenolic Natural Product Library | FDA-Approved & Pharmacopeia Drug Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Mitochondria-Targeted Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Covalent Natural Product Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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