GNE-900 NEW
| Price | $58 | $139 | $223 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: GNE-900 | CAS No.: 1200126-26-6 |
| Purity: 97.18% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | GNE-900 |
| 描述 | GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 μM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity. |
| 體外活性 | GNE-900 (1 μM; 1-48 h; HT-29 cells) induces apoptosis and enhances cleaved PARP expression when combined with gemcitabine (50 nM) in HT-29 cells.[1] |
| 體內(nèi)活性 | GNE-900 (2.5-40 mg/kg, p.o., once; Sprague-Dawley rats) combined with gemcitabine (120 mg/kg) reduced tumor volume and increased DNA damage and γ-H2AX expression levels in rats.[1] |
| 存儲條件 | store at low temperature,keep away from direct sunlight | Shipping with blue ice. |
| 溶解度 | DMSO : 3.85 mg/mL (10.47 mM), Sonication is recommended. |
| 關(guān)鍵字 | GNE-900 | Omeprazole acid |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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