Glibenclamide NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Glibenclamide | CAS No.: 10238-21-8 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Glibenclamide |
| 描述 | Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
| 體外活性 | Administered intravenously at a dose of 25 mg/kg, Glyburide increased sodium (Na) ion excretion by 350% one hour after treatment, without affecting potassium (K) ion excretion, glomerular filtration rate, mean arterial pressure, or heart rate. In awake rats subjected to a saline load, Glyburide dose-dependently increased urinary sodium excretion, while urinary potassium excretion remained largely unchanged. |
| 體內(nèi)活性 | Glyburide enhances the apparent affinity of scavenger receptor class B type I (SR-BI) for high-density lipoprotein (HDL) binding in insulin-secreting cells. It inhibits SR-BI-mediated selective lipid uptake and efflux, with potency similar to its inhibition of ABCA1 (IC50 approximately 275-300 mM). Regardless of the pre-existing relaxation level, Glyburide can also reverse the relaxation induced by pinacidil. At a concentration of 0.03 mM, Glyburide blocks ATP-modulated potassium channels in insulin-secreting cells. It causes a concentration-dependent increase in the IC50 values for BRL34915 and diazoxide, eliminating the relaxation response to minoxidil sulfate. Doses of Glyburide ranging from 10-500 nM proportionately inhibit the relaxation time brought about by potassium channel openers. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 99 mg/mL (200.4 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Cystic fibrosis transmembrane conductance regulator | Inhibitor | Multidrug resistance protein 1 | CFTR | Glibenclamide | fibrosis | regulator | bioenergetics | Cluster of differentiation 243 | inhibit | mitochondrial | cystic | Mitochondrial Metabolism | KcsA | conductance | MDR1 | Autophagy | adipocytes | Pgp | P-glycoprotein | CD243 | ABCB1 | SUR1 | obesity | transmembrane | ATP-sensitive | diabetes | P-gp | Potassium Channel |
| 相關(guān)產(chǎn)品 | Hydroxychloroquine | Guanidine hydrochloride |
| 相關(guān)庫 | 膜蛋白靶向化合物庫 | EMA 上市藥物庫 | 抗癌臨床化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | 離子通道庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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