Ginkgolide B NEW
| Price | $57 | $97 |
| Package | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Ginkgolide B | CAS No.: 15291-77-7 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Ginkgolide B |
| 描述 | Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba. |
| 體外活性 | Oral administration of Ginkgolide B (50 mg/kg) before ischemia notably reduces neuronal damage in the hippocampus of rats. In a mouse model of focal transient ischemia, a 30-minute pretreatment with Ginkgolide B (100 mg/kg, s.c.) diminishes the area of infarction. Additionally, in animals anesthetized with pentobarbital or ethyl carbamate, Ginkgolide B, administered either intravenously (1 mg/kg) or orally (10 mg/kg), inhibits bronchoconstriction and increases hematocrit. |
| 體內(nèi)活性 | Ginkgolide B effectively inhibits platelet-activating factor (PAF) receptors. In cystic cells, it modifies the Ras/MAPK signaling pathway, inducing cell differentiation. In EPC cells, Ginkgolide B promotes cell proliferation and endothelial gene expression by inducing the phosphorylation of eNOS, Akt, and p38, significantly enhancing vascular endothelial growth factor (VEGF)-induced migration responses. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (141.38 mM) Ethanol : 10.6 mg/mL (25 mM) |
| 關(guān)鍵字 | BN52021 | Apoptosis | inhibit | Ginkgolide B | Inhibitor | BN 52021 | Endogenous Metabolite |
| 相關(guān)產(chǎn)品 | Stavudine | Potassium gluconate | 5-Fluorouracil | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Acetaminophen | Sorafenib | Tributyrin | Formamide | Oleamide | Glycerol | Oleic acid |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 萜類天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 風(fēng)味化合物庫 | 植物來源化合物庫 | 抑制劑庫 | 高通量篩選天然產(chǎn)物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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