Gatifloxacin sesquihydrate NEW

Price	$36	$1.2
Package	1kg	1000kg

Min. Order:	1kg
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-04-29

Product Details

Product Name: Gatifloxacin sesquihydrate	CAS No.: 180200-66-2
Min. Order: 1kg	Purity: 99%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/04/29
Lead time: In stock, ready for shipment	Packaging: bag/bottle/drum/IBC
Delivery: By express, by air, by sea	Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details	Name: Mia

1. Materials information

Name	1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate
Synonym	More Synonyms

Description	Gatifloxacin sesquihydrate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin sesquihydrate inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin sesquihydrate can be used to treat bacterial conjunctivitis in vivo.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	Topoisomerase II:36.7 μM (IC50)
In Vitro	Gatifloxacin sesquihydrate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC50 values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively[1]. Gatifloxacin sesquihydrate is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively[1]. Gatifloxacin sesquihydrate exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin sesquihydrate displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935[2]. Gatifloxacin sesquihydrate has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml)[2]. Gatifloxacin sesquihydrate (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin sesquihydrate, respectively[3].
In Vivo	Gatifloxacin sesquihydrate (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis[4]. Animal Model: Female BALB/c mice with Nocardia brasiliensis in the right hind footpad[4] Dosage: 100 mg/kg Administration: Subcutaneous injection; 3 times a day; 30 days Result: Reduced the production of lesions in mice.
References	[1]. Takei M, et al. Inhibitory activities of Gatifloxacin mesylate (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81. [2]. Fukuda H, et al. Antibacterial activity of Gatifloxacin mesylate (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998 Aug;42(8):1917-22. [3]. Yamada C, et al. Gatifloxacin mesylate acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis. Eur J Pharmacol. 2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28. [4]. Daw-Garza A, et al. In vivo therapeutic effect of Gatifloxacin mesylate on BALB/c mice infected with Nocardia brasiliensis.Antimicrob Agents Chemother. 2008 Apr;52(4):1549-50.

Density	1.386 g/cm3
Boiling Point	607.8oC at 760 mmHg
Molecular Formula	C19H22FN3O4.3/2H2O
Molecular Weight	804.834
Flash Point	321.4oC
Exact Mass	804.350586
PSA	195.29000
LogP	4.55550
Vapour Pressure	6.43E-23mmHg at 25°C

Gatifloxacin sesquihydrate MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

Article illustration

3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration

By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration

By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration

4. Contact information

For more details, pls contact us freely.

Email address: mia@fdachem.com

Mob: 86 18336764634

WhatsApp/Skype/Wechat/LINE: 86 18336764634

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

Recommended supplier

Product name	Price		Suppliers	Update time
Gatifloxacin Sesquihydrate	$3490.00/1kg	VIP3Y	Hebei Dangtong Import and export Co LTD	2024-09-10
Gatifloxacin Mesylate	$300.70/1kg	VIP4Y	Hebei Chuanghai Biotechnology Co,.LTD	2024-08-22
Gatifloxacin sesquihydrate	$120.00/1kg	VIP3Y	Hebei Fengjia New Material Co., Ltd	2024-08-08
Gatifloxacin sesquihydrate	$9.00/10g	VIP1Y	Hebei Kangcang new material Technology Co., LTD	2024-03-27
Gatifloxacin sesquihydrate	$0.00/25KG	VIP5Y	Hebei Mojin Biotechnology Co., Ltd	2023-06-20
Gatifloxacin sesquihydrate	$25.00/1KG		XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD	2021-12-15
Gatifloxacin sesquihydrate	$0.00/1Kg/Bag	VIP4Y	WUHAN FORTUNA CHEMICAL CO., LTD	2021-12-02
Gatifloxacin sesquihydrate	$10.00/1KG		Shijiazhuang tongyang Import and Export Co., LTD	2021-08-13
Gatifloxacin sesquihydrate USP/EP/BP	$1.10/1g	VIP4Y	Dideu Industries Group Limited	2021-07-19
Gatifloxacin sesquihydrate	$15.00/1KG		Zhuozhou Wenxi import and Export Co., Ltd	2021-07-10