Product Details
| Product Name:
Gartanin |
CAS No.:
33390-42-0 |
| Purity:
99.85% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Gartanin |
| 描述 | Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways. |
| 體外活性 | The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1] |
| 存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (126.13 mM)
|
| 關(guān)鍵字 | Fungal | Autophagy | inhibit | Gartanin | Inhibitor |
| 相關(guān)產(chǎn)品 | (S)-(+)-Ibuprofen | Astragaloside IV | Navitoclax | Taurochenodeoxycholic Acid | Tauroursodeoxycholate sodium | (-)-Bornyl acetate | Venetoclax | (Iso)-Z-VAD(OMe)-FMK | Anisomycin | Tauroursodeoxycholate | Bentamapimod | Boc-Asp(OMe)-fluoromethyl ketone |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 中藥單體化合物庫 | 神經(jīng)退行性疾病化合物庫 | 植物來源化合物庫 | 抗真菌庫 | 天然產(chǎn)物庫 | 中藥抗炎分子庫 | 煙草單體化合物庫 | 抗感染天然產(chǎn)物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1g |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-01-06 |
United States