Product Details
| Product Name:
Galloflavin |
CAS No.:
568-80-9 |
| Purity:
97.47% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Galloflavin |
| 描述 | Galloflavin is a lactate dehydrogenase inhibitor that inhibits the activity of lactate dehydrogenase. Galloflavin inhibits both human LDH isoforms (type A and type B) by preferentially binding to the free enzyme without competing with substrates or cofactors, with Ki values ??calculated by pyruvate of 5.46 μM (LDH-A) and 15.06 μM (LDH-B). |
| 體外活性 | METHODS: Galloflavin (5, 15 μM) was used to treat SW480 cells, and cell viability was measured and cell migration and wound healing tests were performed to study its effects on the cells in an inflammatory environment.
RESULTS Galloflavin can inhibit the upregulation of cell viability of SW480 cells in an inflammatory microenvironment, and also inhibit their migration and invasion in an inflammatory environment. Wound healing showed inhibition of the migration ability of the cells. [1] |
| 體內(nèi)活性 | METHODS: Galloflavin (5, 15 mg/kg, 15 days) was used to treat tumor xenograft-bearing mice. The tumors were removed and the tumor volume was measured to study its effect on tumors in mice. Western Blot experiments were performed to detect the expression levels of related proteins in mice.
RESULTS Galloflavin can significantly inhibit tumor growth, and the inhibition of tumor growth and tumor volume is time-dependent. Protein detection found that Galloflavin can inhibit the expression of NLRP3, c-Myc and P21. [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (197.72 mM)
DMF : 1.11 mg/mL (4.01 mM), Sonication is recommended.
|
| 關(guān)鍵字 | cancer cell lines | Galloflavin | LDH | cell growth | cell cycle | breast cancer | inhibit | metastasis | Inhibitor | Lactate Dehydrogenase |
| 相關(guān)產(chǎn)品 | Rotenone | Mycophenolate Mofetil | Isomalt |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 代謝化合物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States