Product Details
| Product Name:
FT-1518 |
CAS No.:
1313026-58-2 |
| Purity:
98.80% |
Supply Ability:
10g |
| Release date:
2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | FT-1518 |
| 描述 | FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research. |
| 體外活性 | FT-1518 depicted very good growth inhibitory activity across a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. mTOR kinase inhibition in cells, by FT-1518, resulted in more potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)], and improved anti-proliferative activity as compared with rapamycin.?[1] |
| 體內(nèi)活性 | FT-1518 showed high sustained tumor exposure and target Inhibition in a single oral dose xenograft model. FT-1518 exhibited dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts compared with rapalogs and is poised to enter the clinic with a favorable toxicology profile. [1] |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 2 mg/mL (5.07 mM), Sonication is recommended.
|
| 關(guān)鍵字 | FT-1518 | FT 1518 |
| 相關(guān)產(chǎn)品 | α-Hydroxyglutaric Acid Lithium | L-Leucine | Capivasertib | Sapanisertib | Everolimus | Bimiralisib | Tacrolimus | GDC0084 | TMBIM6 antagonist-1 | P-2281 | Dihydromyricetin | Rapamycin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
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Suppliers |
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$0.00/1kg |
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henan kanbei chemical co.,ltd
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2022-09-20 |
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$99.00/1EA |
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Amikon Limited
|
2018-06-19 |
United States