Product Details
| Product Name:
Firibastat |
CAS No.:
648927-86-0 |
| Purity:
99.88% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Firibastat |
| Description | Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2]. |
| In vivo | Oral administration of QGC-001(0.1-30 mg/kg; p.o.) crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats[2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 30 mg/mL (81.41 mM), Sonication is recommended.
|
| Keywords | hypertensive | inhibit | Inhibitor | angiotensin | Aminopeptidase | pressure | Firibastat | brain | blood |
| Inhibitors Related | Tosedostat | DG051 | L(+)-Leucinol | Acebilustat | Aminopeptidase-IN-1 | ARM1 | SC-57461A | Betulinic acid | α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid | Bestatin hydrochloride | Bestatin | SC-22716 |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States