Fingolimod NEW
| Price | $50 | $126 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: Fingolimod | CAS No.: 162359-55-9 |
| Purity: 99.60% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Fingolimod |
| 描述 | Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). |
| 細胞實驗 | Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1]. |
| 體外活性 | Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1] |
| 存儲條件 | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Methanol : 30 mg/mL (97.57 mM), Sonication is recommended. Ethanol : 7.69 mg/mL (25.01 mM), Sonication is recommended. DMSO : 1 mg/ml, Sonication is recommended. |
| 關(guān)鍵字 | LPL Receptor | Inhibitor | Fingolimod | inhibit | FTY720 | PAK | FTY 720 | Lysophospholipid Receptor | p21 activated kinases |
| 相關(guān)產(chǎn)品 | Fingolimod hydrochloride | SLP9101555 | LX-2931 | Tyloxapol | ASP-4058 | Ki16198 | G-5555 | Siponimod | 5-Aminosalicylic Acid | MP-A08 | S1PR1 modulator 1 | Ozanimod |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | EMA 上市藥物庫 | 植物來源化合物庫 | 藥物功能重定位化合物庫 | 天然產(chǎn)物庫 | 抗病毒庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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