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Postion:Product Catalog >Filorexant
Filorexant
  • Filorexant

Filorexant NEW

Price $30 $68 $118
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: Filorexant CAS No.: 1088991-73-4
Purity: 99.33% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱Filorexant
描述Filorexant (MK-6096) is an orally bioavailable, effective, and selective reversible antagonist of OX1 and OX2 receptors, with (Ki <3 nM).
體外活性Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes [1].
體內(nèi)活性Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg)[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (237.82 mM), Sonication is recommended.
關(guān)鍵字Inhibitor | inhibit | MK6096 | MK 6096 | Orexin Receptor (OX Receptor) | Filorexant | Hypocretin Receptor | HCRT Receptor
相關(guān)產(chǎn)品L-368,899 hydrochloride | YNT-185 | Orexin 2 Receptor Agonist | IPSU | MK-3697 | DORA-22 | Orexin B, rat, mouse Acetate | OXA (17-33) acetate | PF3274167 | ACT-462206 | Seltorexant | TCS 1102
相關(guān)庫疼痛相關(guān)化合物庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌藥物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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