Product Details
| Product Name:
FGTI-2734 |
CAS No.:
1247018-19-4 |
| Purity:
99.36% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | FGTI-2734 |
| 描述 | FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors. |
| 體外活性 | FGTI-2734 (3-30 μM; 72 hours) inhibits both protein prenylation of HDJ2, RAP1A, KRAS and NRAS. FGTI-2734 inhibits KRAS membrane localization in RAS-transformed murine NIH3T3 cells and in mutant KRAS human cancer cells. FGTI-2734 (1-30 μM; 72 hours) induces CASPASE-3 and PARP cleavage in MiaPaCa2, L3.6pl and Calu6 cells. |
| 體內(nèi)活性 | FGTI-2734 (intraperitoneally;100 mg/kg/daily for 18 to 25 days) only inhibits tumor growth in mutant KRAS-dependent tumors but not in mutant KRAS-independent tumors. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (97.92 mM), Sonication is recommended.
|
| 關(guān)鍵字 | pancreatic | patient-derived | geranylgeranyl | farnesyl | inhibit | Farnesyl Transferase | mimetic | Inhibitor | membrane | Ftase | FGTI-2734 | FGTI 2734 | KRAS | C-terminal | transferase | tumors | localization | FGTI2734 |
| 相關(guān)產(chǎn)品 | Serotonin hydrochloride | Risedronate Sodium | Risedronic Acid | 3-Methoxybenzamide | Entacapone | Minodronic acid monohydrate | OU749 | Ibandronate sodium | Testosterone propionate | Alendronate sodium hydrate | Flopropione | (E)-Daporinad |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 代謝化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$47.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-15 |
United States