Ethyl 3,4-dihydroxybenzoate NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ethyl 3,4-dihydroxybenzoate | CAS No.: 3943-89-3 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ethyl 3,4-dihydroxybenzoate |
| Description | Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain. |
| Animal Research | Male Sprague-Dawley rats treated with EDHB (75 mg/kg for 3 days), were subjected to acute HH exposure at 9144 m (30,000 ft) for 5 h. Animals were assessed for transvascular leakage and edema formation in brain and role of key inflammatory markers along with hypoxia responsive genes. |
| In vitro | It is shown that DHB reversibly inhibits both morphological and biochemical differentiation of myoblasts, if it is added to the culture medium before the cell alignment stage.Along with the inhibition of procollagen synthesis, DHB also decreases markedly the production of a collagen-binding glycoprotein (gp46) present in the ER[1]. |
| In vivo | EDHB supplementation effectively scaled down HH induced cerebral edema with concomitant downregulation of brain NF-κB expression.?There was significant curtailment of pro-inflammatory cytokines and cell adhesion molecules.?There was significant downregulation of permeability factor VEGF by EDHB with concomitant increment in hypoxia inducible factor (HIF1α) and anti-inflammatory proteins HO-1 and MT-1 compared to HH control thus accentuating the potential of EDHB as effective hypoxic preconditioning agent in ameliorating HH mediated injury in brain[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 22.5 mg/mL (123.51 mM) |
| Keywords | antioxidant | ROS | Autophagy | NOS | Ethyl 3,4-dihydroxybenzoate | Reactive Oxygen Species | NO Synthase | Apoptosis | Ethyl 3,4 dihydroxybenzoate | Hypoxia-inducible factors | prolyl-hydroxylase | inhibit | HIF-PH | HIF/HIF Prolyl-Hydroxylase | Ethyl protocatechuate | HIFs | Ethyl 3,4dihydroxybenzoate | Inhibitor | collagen | Nitric oxide synthases | mitochondrial |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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