Product Details
| Product Name:
Estredox |
CAS No.:
103562-82-9 |
| Purity:
98.39% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | Estredox |
| Description | Estredox (E2 CDS) is a redox-based estradiol (E2) chemical delivery system.E2-CDS provides sustained and brain-selective delivery of estradiol. |
| In vivo | Injection of Estredox-CDS (30 μL) through the tail vein at a dose of 300 μg/kg body weight in ovariectomized mice triggered transient antidepressant-like behavior in ovariectomized mice. [1]；A single intravenous injection of Estredox-CDS (3 mg/kg) resulted in persistence of E2-Q+ in three distinct brain regions. The sustained and gradual release of estradiol from E2-Q+ is reflected in the time course of plasma estrogen levels. At the end of repeated doses of Estredox-CDS (0.3 mg/kg intravenously once daily for 10 days), we observed a sharp and then gradual decrease in plasma estradiol levels. [3]；In orchiectomized male rats, Estredox reestablished mounting and engraftment for up to 4 weeks after single doses of 0.3 and 3.0 mg/kg iv. The LH suppression effect lasted until day 7 and day 28, respectively. After repeated administration for 10 days at a dose of 0.01 mg/kg iv, significant effects were obtained on day 14. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | IDR90104 | Estredox | E 2 CDS |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States