ESI-09 NEW
| Price | $35 | $56 | $89 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: ESI-09 | CAS No.: 263707-16-0 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱(chēng) | ESI-09 |
| 描述 | ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively. |
| 體外活性 | In WT C57BL/6 mice, ESI-09 (10 mg/kg/d, i.p.) prevents SFG Rickettsiosis by inhibiting EPAC1. |
| 體內(nèi)活性 | ESI-09 specifically inhibits intracellular EPAC-mediated activation of Rap1 and phosphorylation of Akt, as well as EPAC-mediated secretion in pancreatic β-cells. In pancreatic cancer cells induced by 007-AM, ESI-09 reduces cell adhesion and inhibits cell migration. In Schwann cells stimulated by CPT-cAMP, ESI-09 significantly suppresses cell differentiation and myelination. Additionally, in SC neuronal cultures, ESI-09 notably decreases the number of O1-positive and MBP-positive cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 33.1 mg/mL (100 mM) Ethanol : 6.6 mg/mL (20 mM) |
| 關(guān)鍵字 | ESI-09 | Virus Protease | inhibit | ESI 09 | ESI09 | Inhibitor |
| 相關(guān)產(chǎn)品 | EIDD-1931 | Phenytoin sodium | Anthraquinone | Aspirin | Vorinostat | 2-Phenylethanol | L-Lysine hydrochloride | (-)-Epicatechin gallate | PCL 016 | (-)-α-Pinene | Probucol | 4-Phenylbutyric acid |
| 相關(guān)庫(kù) | 高選擇性抑制劑庫(kù) | 表型篩選靶點(diǎn)鑒定庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 抗肥胖化合物庫(kù) | 抗病毒庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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