Product Details
| Product Name:
ERD03 |
CAS No.:
1377897-01-2 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | ERD03 |
| Description | ERD03, with a dissociation constant (Kd) of 17±7 μM, effectively disrupts the EXOSC3-RNA interaction. It has been shown to induce a PCH1B-like phenotype in zebrafish embryos, making it a valuable tool for research into neurological disorders [1]. |
| In vitro | ERD03 at a concentration of 50 μM disrupts G-rich RNA and EXOSC3 interactions by approximately 18% and triggers notable spinal curvature, mirroring the PCH1B phenotype in zebrafish embryos. Additionally, this compound significantly increases ataxin1b mRNA levels (~6-fold) while moderately increasing ataxin1a mRNA levels in embryos. Furthermore, ERD03 leads to a reduction in zebrafish cerebellum size, resulting in cerebella that are half the size of those in control groups treated with DMSO. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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