ER-000444793 NEW
Price | $70 | $163 | $247 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: ER-000444793 | CAS No.: 792957-74-5 |
Purity: 99.55% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | ER-000444793 |
Description | ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM). |
In vitro | ER-000444793 is a small molecule and non-toxic mPTP inhibitor. It also has a mechanism of action independent of CypD inhibition. Both CsA and SfA dose-dependently reduce HTRF signal, showing the displacement of labeled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). However, ER-000444793 has no effect up to a concentration of 50?μM, showing be short of displacement of labelled-CsA from rhCypD protein. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. These data display the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/mL (141.08 mM), Sonication is recommended. |
Keywords | Mitochondrial Metabolism | Inhibitor | inhibit | ER-000444793 | ER000444793 | ER 000444793 |
Inhibitors Related | Imeglimin hydrochloride | Rotenone | Glibenclamide | Tricarballylic acid | Thiabendazole | Boscalid | α-Lipoic Acid | (-)-Epigallocatechin Gallate | Lipoic acid | Daidzin | D-Histidine | Nerol |
Related Compound Libraries | Cuproptosis Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Mitochondria-Targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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