Emtricitabine NEW
| Price | $45 | $68 | $113 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Emtricitabine | CAS No.: 143491-57-0 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Emtricitabine |
| 描述 | Emtricitabine is a nucleoside reverse transcriptase inhibitor with anti-human immunodeficiency virus (HIV) and hepatitis B virus activity, with an EC50 value of 0.01 μM in PBMC cells, and can be used to study HIV infection. |
| 細(xì)胞實(shí)驗(yàn) | EA.hy926 cells were plated in a 12-, 24- or 96-well plates and grown in DMEM media supplemented with 3% FCS. Endothelial cells from PARP+/+and PARP-/- mice were isolated and cultured. Cell viability was determined by the reduction of yellow MTT into a purple formazan product by mitochondrial dehydrogenases of metabolically active cells. Following the treatment period, the experimental medium was removed and 100 μL MTT (1 mg/mL) added. After 1 h incubation, the MTT solution was carefully removed and the purple crystals were solubilized in 100 μL of DMSO. The DMSO was transferred to an ELISA plate and absorbance measured at 550 nm with a 620 nm[3]. |
| 體外活性 | METHODS: Vero E6 cells were treated with Emtricitabine (25, 50, 100 μM), and the SARS-CoV-2 titers obtained before and after treatment were measured. The MTT assay was used to evaluate the cytotoxicity of Emtricitabine against Vero E6 cells. RESULTS Emtricitabine showed anti-SARS-CoV-2 activity at 100 μM (59.6%), 50 μM (43.4%), and 25 μM (33.3%). [5] |
| 體內(nèi)活性 | Reproductive and developmental toxicology studies conducted on emtricitabine show a favorable pre-clinical safety profile. When administered orally at doses up to 1000 mg/kg/day, pregnant animals experienced emtricitabine exposure levels (AUC0→24) approximately 60-fold (in mice) to 120-fold (in rabbits) higher than the human exposure at the recommended 200 mg daily dosage. Findings from a mouse fertility study indicate that emtricitabine does not impact fertility, sperm count, or early embryonic development. Additionally, there was no observed increase in malformations in mouse and rabbit embryofetal toxicology studies, nor did emtricitabine affect the development and fertility of the F1 progeny in a mouse pre- and post-natal study. These results underscore emtricitabine's lack of adverse effects on reproductive and developmental outcomes[6]. |
| 存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (202.22 mM) |
| 關(guān)鍵字 | Inhibitor | HIV | Emtricitabine | inhibit | Reverse Transcriptase | BW 1592 | BW-1592 | Human immunodeficiency virus |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Kaempferol | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Decanedioic acid | Tenofovir |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | EMA 上市藥物庫(kù) | 藥物功能重定位化合物庫(kù) | 抗病毒庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | FDA 上市藥物庫(kù) | 口服活性化合物庫(kù) | 已知活性化合物庫(kù) | 核苷類化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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