Elamipretide NEW
| Price | $50 | $73 | $133 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: Elamipretide | CAS No.: 736992-21-5 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | Elamipretide |
| 描述 | Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. It is a potential therapeutic agent in the rare disease of Barnes syndrome. |
| 體外活性 | METHODS: Rat insulinoma cells, INS1, were treated with Elamipretide (1-10 μM) for 20 h. Cellular mitochondria were detected by Immunofluorescence. RESULTS: Elamipretide prevented mitochondrial breaks induced by nutrient overload, and at the same time had no effect on the mitochondrial morphology of healthy INS1 cells. [1] METHODS: Immortalized human trabecular meshwork cells iHTM and glaucomatous human trabecular cell line GTM3 cells were pretreated with Elamipretide (0.01-1 μM) for 1 h, followed by incubation with H2O2 (200 μM) for 24 h, and LDH release was detected by calorimetric assay. RESULTS: Incubation with H2O2 resulted in a significant increase in LDH release in iHTM and GTM3 cells, and pretreatment with MTP-131 dose-dependently inhibited LDH release. [2] |
| 體內(nèi)活性 | METHODS: To investigate the effects on cognitive sequelae of inflammation and oxidative stress, Elamipretide (5 mg/kg) was administered intraperitoneally to LPS-injected C57BL/6 mice once daily for three days. RESULTS: LPS-induced memory impairment could be attenuated by the mitochondria-targeted antioxidant Elamipretide. [3] METHODS: To test the phenotypic effects on aging in mice, Elamipretide (3 mg/kg) was injected subcutaneously into C57BL/6 mice five times a week for ten months. RESULTS: Elamipretide enhanced healthy aging and cardiac function in both male and female mice, although the specific effects on function varied by sex. In females, the treatment improved cognition and maintained body composition, while in males, rotisserie performance was preserved. [4] |
| 存儲條件 | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 100 mg/mL (156.30 mM), Sonication is recommended. 5% DMSO+95% Saline : 1.45 mg/mL (2.27 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 50 mg/mL(78.15 mM), Sonication is recommended. |
| 關(guān)鍵字 | Elamipretide | SS 31 | SS31 | RX 31 | MTP 131 | MTP131 | RX31 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 多肽分子庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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